More than 100 businesses are located at Van Nuys Airport (VNY), including six major fixed-base operators (FBOs): BaseNet, Clay Lacy Aviation, Maguire Aviation Group, Million Air, Raytheon Aircraft Services and Skytrails Aviation. These operators provide aircraft storage and parking, aviation fuel, aircraft sales, flight instruction, aircraft charter and aircraft maintenance. Some of the FBOs also serve as major leaseholders of airport property, subletting land and buildings to other airport tenants.

In addition, VNY serves as home to numerous companies that provide aviation support activities such as aircraft repairs, avionics, interior work and other specialized functions.